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1.
IEEE J Biomed Health Inform ; 26(5): 2360-2369, 2022 05.
Article in English | MEDLINE | ID: covidwho-1556862

ABSTRACT

Due to the COVID-19 pandemic, vaccine development and community vaccination studies are carried out all over the world. At this stage, the opposition to the vaccine seen in the society or the lack of trust in the developed vaccine is an important factor hampering vaccination activities. In this study, aspect-base sentiment analysis was conducted for USA, U.K., Canada, Turkey, France, Germany, Spain and Italy showing the approach of twitter users to vaccination and vaccine types during the COVID-19 period. Within the scope of this study, two datasets in English and Turkish were prepared with 928,402 different vaccine-focused tweets collected by country. In the classification of tweets, 4 different aspects (policy, health, media and other) and 4 different BERT models (mBERT-base, BioBERT, ClinicalBERT and BERTurk) were used. 6 different COVID-19 vaccines with the highest frequency among the datasets were selected and sentiment analysis was made by using Twitter posts regarding these vaccines. To the best of our knowledge, this paper is the first attempt to understand people's views about vaccination and types of vaccines. With the experiments conducted, the results of the views of the people on vaccination and vaccine types were presented according to the countries. The success of the method proposed in this study in the F1 Score was between 84% and 88% in datasets divided by country, while the total accuracy value was 87%.


Subject(s)
COVID-19 , Deep Learning , Social Media , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19 Vaccines/therapeutic use , Humans , Pandemics/prevention & control , SARS-CoV-2 , Sentiment Analysis , Vaccination
2.
Sci Rep ; 10(1): 21508, 2020 12 09.
Article in English | MEDLINE | ID: covidwho-965423

ABSTRACT

To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.


Subject(s)
Atazanavir Sulfate/therapeutic use , COVID-19 Drug Treatment , COVID-19/metabolism , Heparin/therapeutic use , SARS-CoV-2/metabolism , Atazanavir Sulfate/adverse effects , COVID-19/pathology , Drug Interactions , Heparin/adverse effects , Humans
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